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Molecular and epidemiological studies of Werner syndrome in the Japanese population.

Mechanisms of ageing and development - 1 Dec 1997

Miki T, Nakura J, Ye L, Mitsuda N, Morishima A, Sato N, Kamino K, Ogihara T

Abstract excerpt

Werner syndrome (WS) is an autosomal recessive genetic disease characterized by many age-related features. The gene responsible for WS (WRN) has been isolated and contains a helicase domain, but its function is unknown. Six different mutations throughout the WRN gene have been reported in the Japanese population. We have studied whether patients with a specific mutation exhibit distinct phenotypes from others....

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Identifiers

PMID: 9352494
DOI: 10.1016/s0047-6374(97)00112-7

Genes

WRN

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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