Molecular and epidemiological studies of Werner syndrome in the Japanese population.

doi:10.1016/s0047-6374(97)00112-7

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Article

Molecular and epidemiological studies of Werner syndrome in the Japanese population.

Mechanisms of ageing and development - 1 Dec 1997

Miki T, Nakura J, Ye L, Mitsuda N, Morishima A, Sato N, Kamino K, Ogihara T

Abstract excerpt

Werner syndrome (WS) is an autosomal recessive genetic disease characterized by many age-related features. The gene responsible for WS (WRN) has been isolated and contains a helicase domain, but its function is unknown. Six different mutations throughout the WRN gene have been reported in the Jap...

Topics

Chromosome Mapping
Genes, Recessive
Genotype
Haplotypes
Humans
Japan
Mutation
Pedigree
Phenotype
Werner Syndrome

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