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Article

The stringent response of Mycobacterium tuberculosis is required for long-term survival.

Journal of bacteriology - 1 Sept 2000

Primm T P, Andersen S J, Mizrahi V, Avarbock D, Rubin H, Barry C E

Abstract excerpt

The stringent response utilizes hyperphosphorylated guanine [(p)ppGpp] as a signaling molecule to control bacterial gene expression involved in long-term survival under starvation conditions. In gram-negative bacteria, (p)ppGpp is produced by the activity of the related RelA and SpoT proteins. Mycobacterium tuberculosis contains a single homolog of these proteins (Rel(Mtb)) and responds to nutrient starvation by...

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Identifiers

PMID: 10940033
DOI: 10.1128/JB.182.17.4889-4898.2000
PMCID: PMC111369

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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