Article
Lack of association of HLA class II alleles with peanut allergy.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology - 1 Jun 2006
Shreffler Wayne G, Charlop-Powers Zachary, Sicherer Scott H
Abstract excerpt
BACKGROUND: Peanut allergy is a common and severe phenotype of food allergy with a strong genetic component; HLA class II polymorphisms are attractive candidate genes for this disorder. OBJECTIVE: To determine possible genotypic associations of HLA class II with peanut allergy and attempt replication of previously reported associations. METHODS: Sibling pairs discordant for peanut allergy were genotyped (low...
Topics
- Child
- DNA
- Female
- Genetic Predisposition to Disease
- HLA-DQ Antigens
- HLA-DR Antigens
- Humans
- Male
- Peanut Hypersensitivity