Article
HLA-DR and HLA-DP genotypes and immunoglobulin E responses to common major allergens.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology - 1 May 1994
Young R P, Dekker J W, Wordsworth B P, Schou C, Pile K D, Matthiesen F, Rosenberg W M, Bell J I, Hopkin J M, Cookson W O
Abstract excerpt
In order to test for human histocompatibility leucocyte antigens (HLA) class II restriction of IgE responses, 431 subjects from 83 families were genotyped at the HLA-DR and HLA-DP loci and serotyped for IgE responses to six major allergens from common aero-allergen sources. A possible excess of HLA-DR1 was found in subjects who were responsive to Fel d I compared with those who were not (Odds Ratio (OR) = 2, P =...
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