Effect of chest X-rays on the risk of breast cancer among BRCA1/2 mutation carriers in the international BRCA1/2 carrier cohort study: a report from the EMBRACE, GENEPSO, GEO-HEBON, and IBCCS Collaborators' Group.

doi:10.1200/JCO.2005.03.3126

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Effect of chest X-rays on the risk of breast cancer among BRCA1/2 mutation carriers in the international BRCA1/2 carrier cohort study: a report from the EMBRACE, GENEPSO, GEO-HEBON, and IBCCS Collaborators' Group.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 20 Jul 2006

Andrieu Nadine, Easton Douglas F, Chang-Claude Jenny, Rookus Matti A, Brohet Richard, Cardis Elisabeth, Antoniou Antonis C, Wagner Teresa, Simard Jacques, Evans Gareth, Peock Susan, Fricker Jean-Pierre, Nogues Catherine, Van't Veer Laura, Van Leeuwen Flora E, Goldgar David E

Abstract excerpt

PURPOSE: Women who carry germline mutations in the BRCA1 and BRCA2 genes are at greatly increased risk of breast cancer (BC). Numerous studies have shown that moderate to high doses of ionizing radiation are a risk factor for BC. Because of the role of the BRCA proteins in DNA repair, we hypothesized that BRCA carriers might be more sensitive to ionizing radiation than women in the general population. PATIENTS...

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PMID: 16801631
DOI: 10.1200/JCO.2005.03.3126

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BRCA1
BRCA2

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Effect of chest X-rays on the risk of breast cancer among BRCA1/2 mutation carriers in the international BRCA1/2 carrier cohort study: a report from the EMBRACE, GENEPSO, GEO-HEBON, and IBCCS Collaborators' Group.PMID 16801631Read ↗

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