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BRCA1 and TP53 Gene-Mutations: Family Predisposition and Radioecological Risk of Developing Breast Cancer.

Asian Pacific journal of cancer prevention : APJCP - 1 Jan 2016

Apsalikov Bakytbek, Manambaeva Zukhra, Ospanov Erlan, Massabayeva Meruyert, Zhabagin Kuantkan, Zhagiparova Zhanar, Maximov Vladymir, Voropaeva Elena, Apsalikov Kazbek, Belikhina Tatiana, Abdrahmanov Ramil, Cherepkova Elena, Tanatarov Sayat, Massadykov Adilzhan, Urazalina Naylia

Abstract excerpt

Frequencies of polymorphisms of genes BRCA1 and TP53 in breast cancer (BC) patients with a BC family history and radiation history were assessed and compared in the Semey region of Kazakhstan. The study included 60 women directly irradiated by the activities of the Semipalatinsk test site with a calculated effective equivalent dose of 500 mSv and their first generation descendants (group BC+Her+Exp); 65 women...

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PMID: 27644661

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BRCA1

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