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Variation in breast cancer risk with mutation position, smoking, alcohol, and chest X-ray history, in the French National BRCA1/2 carrier cohort (GENEPSO).

Breast cancer research and treatment - 1 Dec 2011

Lecarpentier Julie, Noguès Catherine, Mouret-Fourme Emmanuelle, Stoppa-Lyonnet Dominique, Lasset Christine, Caron Olivier, Fricker Jean-Pierre, Gladieff Laurence, Faivre Laurence, Sobol Hagay, Gesta Paul, Frenay Marc, Luporsi Elisabeth, Coupier Isabelle, Lidereau Rosette, Andrieu Nadine

Abstract excerpt

Germline mutations in BRCA1/2 confer a high risk of breast cancer (BC), but the magnitude of this risk varies according to various factors. Although controversial, there are data to support the hypothesis of allelic-risk heterogeneity. We assessed variation in BC risk according to the location of mutations recorded in the French study GENEPSO. Since the women in this study were selected from high-risk families,...

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Source

Identifiers

PMID: 21761160
DOI: 10.1007/s10549-011-1655-3

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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