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Article

Radiation-Associated Secondary Malignancies in BRCA Mutation Carriers Treated for Breast Cancer.

International journal of radiation oncology, biology, physics - 1 Jun 2020

Schlosser Shir, Rabinovitch Rachel, Shatz Zina, Galper Shira, Shahadi-Dromi Ilanit, Finkel Sara, Jacobson Galia, Rasco Adi, Friedman Eitan, Laitman Yael, Evron Ella, Bernstein Rinat, Weiss Ilana, Sklair-Levy Miri, Ben-David Merav A

Abstract excerpt

PURPOSE: Radiation therapy (RT), a standard breast cancer (BC) treatment modality, is associated with a small increased risk of in-field second primary malignancy (SPM). SPM rates after RT in BRCA mutation carriers have rarely been reported. An elevated risk of SPM would affect the safety of breast conservation for early BC or prophylactic radiation as a method of prevention. We analyzed a population of BRCA...

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PMID: 32084523
DOI: 10.1016/j.ijrobp.2020.02.020

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