Exposure to diagnostic radiation and risk of breast cancer among carriers of BRCA1/2 mutations: retrospective cohort study (GENE-RAD-RISK).

doi:10.1136/bmj.e5660

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Article

Exposure to diagnostic radiation and risk of breast cancer among carriers of BRCA1/2 mutations: retrospective cohort study (GENE-RAD-RISK).

BMJ (Clinical research ed.) - 6 Sept 2012

Pijpe Anouk, Andrieu Nadine, Easton Douglas F, Kesminiene Ausrele, Cardis Elisabeth, Noguès Catherine, Gauthier-Villars Marion, Lasset Christine, Fricker Jean-Pierre, Peock Susan, Frost Debra, Evans D Gareth, Eeles Rosalind A, Paterson Joan, Manders Peggy, van Asperen Christi J, Ausems Margreet G E M, Meijers-Heijboer Hanne, Thierry-Chef Isabelle, Hauptmann Michael, Goldgar David, Rookus Matti A, van Leeuwen Flora E

Abstract excerpt

OBJECTIVE: To estimate the risk of breast cancer associated with diagnostic radiation in carriers of BRCA1/2 mutations. DESIGN: Retrospective cohort study (GENE-RAD-RISK). SETTING: Three nationwide studies (GENEPSO, EMBRACE, HEBON) in France, United Kingdom, and the Netherlands, PARTICIPANTS: 1993 female carriers of BRCA1/2 mutations recruited in 2006-09. MAIN OUTCOME MEASURE: Risk of breast cancer estimated with...

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PMID: 22956590
DOI: 10.1136/bmj.e5660
PMCID: PMC3435441

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BRCA1

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