Article
Association between serum beta-carotene levels and decline of cognitive function in high-functioning older persons with or without apolipoprotein E 4 alleles: MacArthur studies of successful aging.
The journals of gerontology. Series A, Biological sciences and medical sciences - 1 Jun 2006
Hu Peifeng, Bretsky Philip, Crimmins Eileen M, Guralnik Jack M, Reuben David B, Seeman Teresa E
Abstract excerpt
BACKGROUND: Growing evidence from animal studies suggests an interaction between antioxidants and apolipoprotein E (APOE) alleles on cognitive functioning. We used data from a 7-year cohort study of high-functioning older persons to explore whether the associations between serum beta-carotene level and subsequent decline of cognitive function differed by APOE 4 genotype. METHODS: Baseline information on...
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