Article
[Association of aldosterone synthase gene -344T/C polymorphism with plasma aldosterone and angiotensin II concentration in hypertensive patients].
Zhonghua yi xue za zhi - 25 Apr 2006
Hu Bang-chuan, Chu Shao-li, Wang Ji-guang, Wang Zhi-hua, Wang Gu-liang, Gao Ping-jin, Zhu Ding-liang
Abstract excerpt
OBJECTIVE: To investigate the association of aldosterone synthase (CYP11B2) -344T/C polymorphism with plasma renin activity (PRA), and concentrations of angiotensin II (Ang II) and aldosterone (Aldo) in patients with essential hypertension (EH). METHODS: 421 EH patients, 296 males and 125 females, aged 56.3 +/- 11.2, and 207 sex and aged-matched normotensive subjects were genotyped for the CYP11B2 -344T/C...
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