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Baculovirus-Expressed Constructs Induce Immunoglobulin G That Recognizes VAR2CSA onPlasmodium falciparum- Infected Erythrocytes

21 Jun 2006

Abstract excerpt

We raised specific antisera against recombinant VAR2CSA domains produced in Escherichia coli and in insect cells. All were reactive in enzyme-linked immunosorbent assay, but only insect cell-derived constructs induced immunoglobulin G (IgG) that was reactive with native VAR2CSA on the surface of infected erythrocytes. Our data show that five of the six VAR2CSA Duffy-binding-like domains are surface exposed and...

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PMID: 16790811
DOI: 10.1128/iai.01617-05

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