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Blood Group Antigen Recognition via the Group A Streptococcal M Protein Mediates Host Colonization

25 Jan 2017

Abstract excerpt

Streptococcus pyogenes (group A streptococcus [GAS]) is responsible for over 500,000 deaths worldwide each year. The highly virulent M1T1 GAS clone is one of the most frequently isolated serotypes from streptococcal pharyngitis and invasive disease. The oral epithelial tract is a niche highly abundant in glycosylated structures, particularly those of the ABO(H) blood group antigen family. Using a high-throughput...

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PMID: 28119471
DOI: 10.1128/mbio.02237-16

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