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Article

Effect of Drug Resistance on the Generation of Secondary Cases of Tuberculosis

15 Dec 2003

Abstract excerpt

BACKGROUND: The results of animal studies suggest that isoniazid-resistant strains of Mycobacterium tuberculosis are less pathogenic than isoniazid-susceptible strains. Here, we assess the relative pathogenicity of drug-resistant and drug-susceptible strains, in a human population. METHODS: We linked IS6110 genotype patterns of M. tuberculosis strains with drug-susceptibility test results and epidemiologic...

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PMID: 14673768
DOI: 10.1086/379895

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