Article
Genetic screens for mutations affecting development of Xenopus tropicalis.
PLoS genetics - 1 Jun 2006
Goda Tadahiro, Abu-Daya Anita, Carruthers Samantha, Clark Matthew D, Stemple Derek L, Zimmerman Lyle B
Abstract excerpt
We present here the results of forward and reverse genetic screens for chemically-induced mutations in Xenopus tropicalis. In our forward genetic screen, we have uncovered 77 candidate phenotypes in diverse organogenesis and differentiation processes. Using a gynogenetic screen design, which minimizes time and husbandry space expenditures, we find that if a phenotype is detected in the gynogenetic F2 of a given...
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