Simple vertebrate models for chemical genetics and drug discovery screens: lessons from zebrafish and Xenopus.

Abstract excerpt

Chemical genetics uses small molecules to modulate protein function and, in principle, has the potential to perturb any biochemical event in a complex cellular context. The application of chemical genetics to dissect biological processes has become an attractive alternative to mutagenesis screens due to its technical simplicity, inexpensive reagents, and low-startup costs. In vertebrates, only fish and amphibians...

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