Article
Role of glutathione-S-transferase and codon 72 of P53 genotypes in epithelial ovarian cancer patients.
Journal of cancer research and clinical oncology - 1 Aug 2006
Morari Elaine Cristina, Lima Andre Bacellar Costa, Bufalo Natassia Elena, Leite Janaina Luisa, Granja Fabiana, Ward Laura Sterian
Abstract excerpt
PURPOSE: A series of polymorphisms in germ-line DNA have been investigated in an effort to delineate polygenic models of cancer susceptibility and prognosis. As low-penetrance susceptibility genes may combine additively or multiplicatively and contribute to cancer incidence and to the response to chemotherapy, we studied GSTT1, GSTM1, GSTO2, GSTP1 and codon 72 of p53 genotype profiles in ovarian cancer patients....
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