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Article

The Role of Glutathione Transferase Omega-Class Variant Alleles in Individual Susceptibility to Ovarian Cancer.

International journal of molecular sciences - 3 May 2024

Simic Petar, Coric Vesna, Pljesa Igor, Savic-Radojevic Ana, Zecevic Nebojsa, Kocic Jovana, Simic Tatjana, Pazin Vladimir, Pljesa-Ercegovac Marija

Abstract excerpt

The tumor microenvironment is affected by reactive oxygen species and has been suggested to have an important role in ovarian cancer (OC) tumorigenesis. The role of glutathione transferases (GSTs) in the maintenance of redox balance is considered as an important contributing factor in cancer, including OC. Furthermore, GSTs are mostly encoded by highly polymorphic genes, which further highlights their potential...

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Identifiers

PMID: 38732205
DOI: 10.3390/ijms25094986
PMCID: PMC11084357

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