Article
Glutathione S-transferase GSTM1, GSTT1 and p53 codon 72 polymorphisms in human tumor cells.
Human cell - 1 Dec 2003
Ueda Masatsugu, Hung Yao-Ching, Terai Yoshito, Kanda Koji, Takehara Mikio, Yamashita Hikari, Yamaguchi Hiroyuki, Akise Daisuke, Yasuda Masayuki, Nishiyama Koji, Ueki Minoru
Abstract excerpt
The genes of the glutathione S-transferase (GST) family encode enzymes that appear to be critical in cellular protection against the cytotoxic effects, whereas p53 is a tumor suppressor gene. Despite a large number of studies on germline polymorphisms of GSTM1, GSTT1 and p53 genes, there have been very few reports on genotyping of these genes in human malignant tumor cells. In this study, we investigated GSTM1,...
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