Article
Family-based study of markers at the 5'-flanking region of the human dopamine transporter gene reveals potential association with schizophrenic psychoses.
European archives of psychiatry and clinical neuroscience - 1 Oct 2006
Stöber Gerald, Sprandel Julia, Jabs Burkhard, Pfuhlmann Bruno, Möller-Ehrlich Kerstin, Knapp Michael
Abstract excerpt
The dopamine hypothesis of schizophrenia proposes an inherited or acquired presynaptic hyperactivity of dopaminergic neurons. The human dopamine transporter gene (hSLC6A3; hDAT) represents one major mechanism for the termination of dopaminergic neurotransmission. This study examines the degree of genetic association of the 5'-untranslated region (5'-UTR) of the hSLC6A3 to schizophrenia in a family-based...
Topics
- 5' Flanking Region
- Adult
- Alleles
- Base Sequence
- DNA Mutational Analysis
- Dopamine Plasma Membrane Transport Proteins
- Family
- Female
- Genotype
- Haplotypes
- Humans
- Male
- Polymorphism, Restriction Fragment Length