Article
Family-based study of markers at the 5'-flanking region of the human dopamine transporter gene reveals potential association with schizophrenic psychoses.
European archives of psychiatry and clinical neuroscience - 1 Oct 2006
Stöber Gerald, Sprandel Julia, Jabs Burkhard, Pfuhlmann Bruno, Möller-Ehrlich Kerstin, Knapp Michael
Abstract excerpt
The dopamine hypothesis of schizophrenia proposes an inherited or acquired presynaptic hyperactivity of dopaminergic neurons. The human dopamine transporter gene (hSLC6A3; hDAT) represents one major mechanism for the termination of dopaminergic neurotransmission. This study examines the degree of genetic association of the 5'-untranslated region (5'-UTR) of the hSLC6A3 to schizophrenia in a family-based...
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