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Article

Benzodiazepines act on GABAA receptors via two distinct and separable mechanisms.

Nature neuroscience - 1 Dec 2000

Walters R J, Hadley S H, Morris K D, Amin J

Abstract excerpt

Benzodiazepines (BZs) act on gamma-aminobutyric acid type A (GABAA) receptors such as alpha1beta2gamma2 through key residues within the N-terminal region of alpha subunits, to render their sedative and anxiolytic actions. However, the molecular mechanisms underlying the BZs' other clinical actions are not known. Here we show that, with low concentrations of GABA, diazepam produces a biphasic potentiation for the...

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Identifiers

PMID: 11100148
DOI: 10.1038/81800

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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