Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Expression of mdr-1/P-glycoprotein in human neuroblastoma.

The American journal of pathology - 1 Aug 1991

Bates S E, Shieh C Y, Tsokos M

Abstract excerpt

Increased expression of the mdr-1 gene encoding the drug efflux pump P-glycoprotein is a well-established mediator of acquired drug resistance in vitro, and a similar role has been hypothesized in vivo in human malignancy. Because expression of mdr-1 is increased in neuroblastoma cell lines by differentiating agents, the authors hypothesized a similar correlation with differentiation in vivo in neuroblastomas. In...

Topics

ATP Binding Cassette Transporter, Subfamily B, Member 1
Drug Resistance
Genes
Humans
Immunohistochemistry
Membrane Glycoproteins
Neuroblastoma
Nucleic Acid Hybridization
Phenotype
RNA, Neoplasm
Ribonucleases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Open in PubMed Open full text

Identifiers

PMID: 1678252
PMCID: PMC1886082

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1678252-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Expression of mdr-1/P-glycoprotein in human neuroblastoma.PMID 1678252Read ↗

P-Glycoprotein Expression as a Predictor of the Outcome of Therapy for NeuroblastomaSemantic proximity Read ↗

Increased malignant behavior in neuroblastoma cells with acquired multi-drug resistance does not depend on P-gp expression.Semantic proximity Read ↗

Expression of the multidrug resistance, MDR1, gene in neuroblastomas.Semantic proximity Read ↗

Expression of P-glycoprotein in human glioma cell lines and surgical glioma specimensSemantic proximity Read ↗

MYCN Enhances P-gp/MDR1 Gene Expression in the Human Metastatic Neuroblastoma IGR-N-91 ModelSemantic proximity Read ↗

MRP1 gene expression level regulates the death and differentiation response of neuroblastoma cellsSemantic proximity Read ↗

Expression of the Gene for Multidrug-Resistance–Associated Protein and Outcome in Patients with NeuroblastomaSemantic proximity Read ↗

The expression of P-glycoprotein is causally related to a less aggressive phenotype in human osteosarcoma cells.Semantic proximity Read ↗

Role of chemotherapy resistance genes in outcome of neuroblastomaSemantic proximity Read ↗

Quantitative analysis of multidrug-resistance mdr1 gene expression in head and neck cancer by real-time RT-PCR.Semantic proximity Read ↗

Significance of MDR1 and multiple drug resistance in refractory human epileptic brainSemantic proximity Read ↗

Expression of multidrug resistance gene mdr1 mRNA in a subset of normal bone marrow cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.