In vivo development and in vitro characterization of a subclone of murine P388 leukemia resistant to bis(diphenylphosphine)ethane.

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Article

In vivo development and in vitro characterization of a subclone of murine P388 leukemia resistant to bis(diphenylphosphine)ethane.

Molecular pharmacology - 1 Jan 1991

Hoke G D, McCabe F L, Faucette L F, Bartus J O, Sung C M, Jensen B D, Heys J R, Rush G F, Alberts D W, Johnson R K

Abstract excerpt

Bis(diphenylphosphine)ethane (DPPE) and its gold coordination complexes have demonstrated antitumor activity in transplantable tumor models. This report describes the development of a P388 cell line (P388/DPPEc) that is resistant to DPPE and its analogues and the in vitro characterization of the cross-resistance of this subline to various antitumor and cytotoxic agents. The P388/DPPE tumor cell line was developed...

Topics

Adenosine Triphosphate
Animals
Antineoplastic Agents
Carbon Dioxide
Cell Line
Drug Resistance
Flow Cytometry
Gold
Leukemia P388
Mice
Mitochondria

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Organogold Compounds

Organometallic Compounds

Organophosphorus Compounds

Phenotype

Rhodamine 123

Rhodamines

Source

Open in PubMed

Identifiers

PMID: 1898982

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1898982-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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