Article
CD4+CD25bright T cells in human intestinal lamina propria as regulatory cells.
Journal of immunology (Baltimore, Md. : 1950) - 1 Sept 2004
Makita Shin, Kanai Takanori, Oshima Shigeru, Uraushihara Koji, Totsuka Teruji, Sawada Taisuke, Nakamura Tetsuya, Koganei Kazutaka, Fukushima Tsuneo, Watanabe Mamoru
Abstract excerpt
It is well known that immune responses in the intestine remain in a state of controlled inflammation, suggesting that not only active suppression by regulatory T cells plays an important role in the normal intestinal homeostasis, but also its dysregulation leads to the development of inflammatory bowel disease. In this study, we demonstrate that the CD4(+)CD25(bright) T cells reside in the human intestinal lamina...
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