Article
A graphical assessment of p-values from sliding window haplotype tests of association to identify asthma susceptibility loci on chromosome 11q.
BMC genetics - 14 Jun 2006
Mathias Rasika A, Gao Peisong, Goldstein Janet L, Wilson Alexander F, Pugh Elizabeth W, Furbert-Harris Paulette, Dunston Georgia M, Malveaux Floyd J, Togias Alkis, Barnes Kathleen C, Beaty Terri H, Huang Shau-Ku
Abstract excerpt
BACKGROUND: Past work on asthmatic African American families revealed a strong linkage peak with modest evidence of association on chromosome 11q. Here, we perform tests of association for asthma and a panel of 609 SNPs in African American subjects using a sliding window approach. While efficient in screening a region of dense genotyping, this approach does create some problems: high numbers of tests,...
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