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Article

Genetic variation in the CCL18-CCL3-CCL4 chemokine gene cluster influences HIV Type 1 transmission and AIDS disease progression.

American journal of human genetics - 1 Jul 2006

Modi William S, Lautenberger James, An Ping, Scott Kevin, Goedert James J, Kirk Gregory D, Buchbinder Susan, Phair John, Donfield Sharyne, O'Brien Stephen J, Winkler Cheryl

Abstract excerpt

CCL3 (MIP-1 alpha), CCL4 (MIP-1 beta), and CCL18 (DC-CK1/PARC/AMAC-1) are potent chemoattractants produced by macrophages, natural killer cells, fibroblasts, mast cells, CD4(+) T cells, and CD8(+) T cells. CCL3 and CCL4 are natural ligands for the primary human immunodeficiency virus type 1 (HIV-1) coreceptor CCR5 and are also known to activate and enhance the cytotoxicity of natural killer cells. Genomic DNAs...

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Source

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Identifiers

PMID: 16773571
DOI: 10.1086/505331
PMCID: PMC1474130

Genes

CCL3
CCL4
CCL18
MIP
CCR5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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