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Analysis of the B-RAFV600E mutation in cutaneous melanoma patients with occupational sun exposure

14 Jan 2014

Abstract excerpt

Sun-exposure is one of the risk factors associated with the development of a cutaneous neoplasm. In melanoma, the Ras-Raf-MEK-ERK (MAPK) signaling pathway is constitutively activated through multiple mechanisms, including B-Raf mutation. It has been hypothesized that B-Raf mutations in melanocytic lesions arise from DNA damage induced by ultraviolet (UV) radiation. However, it is still discussed if B-Raf...

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PMID: 24424406
DOI: 10.3892/or.2014.2977

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