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Article

Preponderance of the oncogenic V599E and V599K mutations in B-raf kinase domain is enhanced in melanoma cutaneous/subcutaneous metastases.

BMC cancer - 3 Jun 2005

Deichmann Martin, Thome Marianne, Benner Axel, Kirschner Martin, Hassanzadeh Judith, Kurzen Hjalmar

Abstract excerpt

BACKGROUND: Downstream of Ras, the serine/threonine kinase B-raf has been reported to be mutated, among other carcinomas, in a substantial subset of primary melanomas with a preponderance of mutations within the kinase domain including the activating V599E and V599K transitions. METHODS: We here investigated a representative series of 60 resection specimens of cutaneous and subcutaneous melanoma metastases for...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Neoplasm Metastasis

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Share to Proto-Oncogene Proteins B-raf

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Identifiers

PMID: 15935100
DOI: 10.1186/1471-2407-5-58
PMCID: PMC1164406

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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