Article
Distinction of low grade from high grade human ovarian carcinomas on the basis of losses of heterozygosity on chromosomes 3, 6, and 11 and HER-2/neu gene amplification.
Cancer research - 1 Aug 1991
Zheng J P, Robinson W R, Ehlen T, Yu M C, Dubeau L
Abstract excerpt
We examined the frequencies of loss of heterozygosity at 13 different loci distributed on 9 chromosomes in 30 human ovarian carcinomas. The same tumors were also examined for the presence of amplification of the HER-2/neu and H-ras protooncogenes. The results confirmed earlier findings that losse...
Topics
- Animals
- Chromosome Aberrations
- Chromosomes, Human, Pair 11
- Chromosomes, Human, Pair 3
- Chromosomes, Human, Pair 6
- Cricetinae
- Female
- Gene Amplification
- Genes, ras
- Heterozygote
- Humans
- Oncogene Proteins, Viral
- Ovarian Neoplasms
- Phenotype
- Receptor, ErbB-2