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Article

Mutation of K-RAS protooncogene and loss of heterozygosity on 6q27 in serous and mucinous ovarian carcinomas.

Cancer genetics and cytogenetics - 15 Apr 2000

Suzuki M, Saito S, Saga Y, Ohwada M, Sato I

Abstract excerpt

The genetic etiology of serous and mucinous ovarian carcinomas was investigated in 76 affected patients, focusing on the possible loss of heterozygosity (LOH) involving chromosome band 6q27 and K-RAS mutations at codon 12. The incidence of LOH in 6q27 (6q27 LOH) was 41% in 64 informative cases; 53% (20/38) and 23% (6/26) in cases of serous ovarian carcinoma and in those of mucinous ovarian carcinoma,...

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PMID: 10748293
DOI: 10.1016/s0165-4608(99)00192-2

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Source receipt: pubmed, retrieved 7 Sept 2026.

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