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Article

Evaluating gene expression in C57BL/6J and DBA/2J mouse striatum using RNA-Seq and microarrays.

PloS one - 24 Mar 2011

Bottomly Daniel, Walter Nicole A R, Hunter Jessica Ezzell, Darakjian Priscila, Kawane Sunita, Buck Kari J, Searles Robert P, Mooney Michael, McWeeney Shannon K, Hitzemann Robert

Abstract excerpt

C57BL/6J (B6) and DBA/2J (D2) are two of the most commonly used inbred mouse strains in neuroscience research. However, the only currently available mouse genome is based entirely on the B6 strain sequence. Subsequently, oligonucleotide microarray probes are based solely on this B6 reference sequence, making their application for gene expression profiling comparisons across mouse strains dubious due to their...

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PMID: 21455293
DOI: 10.1371/journal.pone.0017820
PMCID: PMC3063777

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