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Article

The mutant leucine-zipper domain impairs both dimerization and suppressive function of Foxp3 in T cells.

Proceedings of the National Academy of Sciences of the United States of America - 20 Jun 2006

Chae Wook-Jin, Henegariu Octavian, Lee Sang-Kyou, Bothwell Alfred L M

Abstract excerpt

Regulatory T cells that express the Foxp3 transcription factor play important roles in preventing autoimmune diseases. Although several studies have demonstrated that the lack of the forkhead DNA-binding domain of Foxp3 caused severe autoimmune disease in scurfy mutant mice, the other functional...

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Identifiers

PMID: 16769892
DOI: 10.1073/pnas.0600225103
PMCID: PMC1480458

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16769892-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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