Article
The mutant leucine-zipper domain impairs both dimerization and suppressive function of Foxp3 in T cells.
Proceedings of the National Academy of Sciences of the United States of America - 20 Jun 2006
Chae Wook-Jin, Henegariu Octavian, Lee Sang-Kyou, Bothwell Alfred L M
Abstract excerpt
Regulatory T cells that express the Foxp3 transcription factor play important roles in preventing autoimmune diseases. Although several studies have demonstrated that the lack of the forkhead DNA-binding domain of Foxp3 caused severe autoimmune disease in scurfy mutant mice, the other functional domains of Foxp3 are less well characterized. Here, we show that the deletion of glutamic acid (DeltaE250) in the...
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