The impact of human EGFR kinase domain mutations on lung tumorigenesis and in vivo sensitivity to EGFR-targeted therapies.

doi:10.1016/j.ccr.2006.04.022

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Article

The impact of human EGFR kinase domain mutations on lung tumorigenesis and in vivo sensitivity to EGFR-targeted therapies.

Cancer cell - 1 Jun 2006

Ji Hongbin, Li Danan, Chen Liang, Shimamura Takeshi, Kobayashi Susumu, McNamara Kate, Mahmood Umar, Mitchell Albert, Sun Yangping, Al-Hashem Ruqayyah, Chirieac Lucian R, Padera Robert, Bronson Roderick T, Kim William, Jänne Pasi A, Shapiro Geoffrey I, Tenen Daniel, Johnson Bruce E, Weissleder Ralph, Sharpless Norman E, Wong Kwok-Kin

Abstract excerpt

To understand the role of human epidermal growth factor receptor (hEGFR) kinase domain mutations in lung tumorigenesis and response to EGFR-targeted therapies, we generated bitransgenic mice with inducible expression in type II pneumocytes of two common hEGFR mutants seen in human lung cancer. Both bitransgenic lines developed lung adenocarcinoma after sustained hEGFR mutant expression, confirming their oncogenic...

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PMID: 16730237
DOI: 10.1016/j.ccr.2006.04.022

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EGFR

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