Article
DRB genotyping supports recessive inheritance of DR3-associated susceptibility to insulin-dependent diabetes mellitus.
American journal of human genetics - 1 Jul 1991
Jenkins D, Fletcher J, Penny M A, Mijovic C H, Jacobs K H, Bradwell A R, Barnett A H
Abstract excerpt
The mode of inheritance of HLA-associated susceptibility to insulin-dependent diabetes mellitus was investigated by the antigen genotype frequency among patients method in a white Caucasian population and a North Indian Asian population. DR genotypes were determined by DRB/DQB RFLP analysis. In white Caucasians, simple recessive and simple additive inheritance of a single HLA-associated disease susceptibility...
Topics
- Diabetes Mellitus, Type 1
- Genes, Recessive
- Genotype
- HLA-DR Antigens
- HLA-DR3 Antigen
- Humans
- India
- Polymorphism, Restriction Fragment Length
- White People