Article

SUMOylation differentially regulates SMCHD1 complex formation and function in a genomic context-specific manner

2024-10-13

Abstract excerpt

Structural Maintenance of Chromosomes Hinge Domain Containing 1 (SMCHD1) is a chromatin repressor regulating gene expression and chromatin architecture of distinct autosomal and X-chromosomal loci. SMCHD1 mutations cause derepression of the D4Z4 macrosatellite repeat-embedded DUX4 gene in skeletal muscle of facioscapulohumeral muscular dystrophy (FSHD) patients Little is known about the regulation and post-transl...

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Literature Corpus work: bb3c4782-4674-5a21-ab01-5c2490c50c53
DOI: 10.1101/2024.10.13.618066

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