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Article

Chemical synthesis of mouse cripto CFC variants.

Proteins - 15 Aug 2006

Marasco Daniela, Saporito Angela, Ponticelli Salvatore, Chambery Angela, De Falco Sandro, Pedone Carlo, Minchiotti Gabriella, Ruvo Menotti

Abstract excerpt

We report for the first time the chemical synthesis of refolded CFC domain of mouse Cripto (mCFC) and of two variants bearing mutations on residues W107 and H104 involved in Alk4 binding. The domains undergo spontaneous and quantitative refolding in about 4 h, yet with very different kinetics. Disulfide linkages have been assessed by enzyme digestion and mass spectrometry analysis of resulting fragments, and the...

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PMID: 16752415
DOI: 10.1002/prot.21043

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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