Article
A recombinant technique for mapping functional sites of heterotrimeric collagen helices: Collagen IV CB3 fragment as a prototype for integrin binding.
The Journal of biological chemistry - 1 Jul 2023
Boudko Sergei P, Konopka Elizabeth H, Kim Woojin, Taga Yuki, Mizuno Kazunori, Springer Timothy A, Hudson Billy G, Moy Terence I, Lin Fu-Yang
Abstract excerpt
Collagen superfamily of proteins is a major component of the extracellular matrix. Defects in collagens underlie the cause of nearly 40 human genetic diseases in millions of people worldwide. Pathogenesis typically involves genetic alterations of the triple helix, a hallmark structural feature that bestows exceptional mechanical resistance to tensile forces and a capacity to bind a plethora of macromolecules....
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