Article
Structural and Molecular Evidence Suggesting Coronavirus-driven Evolution of Mouse Receptor.
The Journal of biological chemistry - 10 Feb 2017
Peng Guiqing, Yang Yang, Pasquarella Joseph R, Xu Liqing, Qian Zhaohui, Holmes Kathryn V, Li Fang
Abstract excerpt
Hosts and pathogens are locked in an evolutionary arms race. To infect mice, mouse hepatitis coronavirus (MHV) has evolved to recognize mouse CEACAM1a (mCEACAM1a) as its receptor. To elude MHV infections, mice may have evolved a variant allele from the Ceacam1a gene, called Ceacam1b, producing mCEACAM1b, which is a much poorer MHV receptor than mCEACAM1a. Previous studies showed that sequence differences between...
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