Article
IGHMBP2 Thr671Ala polymorphism might be a modifier for the effects of cigarette smoking and PAH-DNA adducts to breast cancer risk.
Breast cancer research and treatment - 1 Sept 2006
Shen Jing, Terry Mary Beth, Gammon Marilie D, Gaudet Mia M, Teitelbaum Susan L, Eng Sybil M, Sagiv Sharon K, Neugut Alfred I, Santella Regina M
Abstract excerpt
Laboratory and bioinformatics studies have suggested that immunoglobulin mu-binding protein 2 (IGHMBP2) is involved in DNA repair, replication and recombination. Using 1067 cases and 1110 controls from a population-based case-control study, we sought to clarify the potential role of the IGHMBP2 Thr671Ala polymorphism (A to G substitution) alone and as a modifier of the effects for cigarette smoking and PAH-DNA...
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