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Article

Structural features of the cytoplasmic region of CD4 required for internalization.

The EMBO journal - 1 Feb 1990

Shin J, Doyle C, Yang Z, Kappes D, Strominger J L

Abstract excerpt

CD4, the T cell surface antigen, is phosphorylated and internalized when T cells are activated or treated with a phorbol ester, PMA. The actual phosphorylation sites have been identified and the role of phosphorylation of each on CD4 internalization investigated. Seven different mutants, in each of which one, two or all three of the serine residues of the cytoplasmic region was modified to alanine(s) (CD4.SA...

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Identifiers

PMID: 2105883
DOI: 10.1002/j.1460-2075.1990.tb08127.x
PMCID: PMC551683

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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