Article
Structural features of the cytoplasmic region of CD4 required for internalization.
The EMBO journal - 1 Feb 1990
Shin J, Doyle C, Yang Z, Kappes D, Strominger J L
Abstract excerpt
CD4, the T cell surface antigen, is phosphorylated and internalized when T cells are activated or treated with a phorbol ester, PMA. The actual phosphorylation sites have been identified and the role of phosphorylation of each on CD4 internalization investigated. Seven different mutants, in each...
Topics
- Amino Acid Sequence
- CD4 Antigens
- Cell Line
- Cell Membrane
- Endocytosis
- HeLa Cells
- Humans
- Kinetics
- Molecular Sequence Data
- Mutation
- Peptide Mapping
- Phosphopeptides
- Phosphorylation
- Serine
- T-Lymphocytes
- Tetradecanoylphorbol Acetate