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Article

Mutant Gly482 and Thr482 ABCG2 mediate high-level resistance to lipophilic antifolates.

Cancer chemotherapy and pharmacology - 1 Dec 2006

Bram Eran, Ifergan Ilan, Shafran Assaf, Berman Bluma, Jansen Gerrit, Assaraf Yehuda G

Abstract excerpt

Cellular uptake of hydrophilic antifolates proceeds via the reduced folate carrier whereas lipophilic antifolates enter cells by diffusion. Recently we have shown that transfectant cells overexpressing the mutant G482 ABCG2 displayed 120-6,250-fold resistance to hydrophilic antifolates than untransfected cells upon 4 h drug exposure, but lost almost all their antifolate resistance upon 72 h drug exposure (Shafran...

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Share to ATP Binding Cassette Transporter, Subfamily G, Member 2
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16612649
DOI: 10.1007/s00280-006-0230-9

Genes

ABCG2

Provenance

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Mutant Gly482 and Thr482 ABCG2 mediate high-level resistance to lipophilic antifolates.PMID 16612649Read ↗

ABCG2 harboring the Gly482 mutation confers high-level resistance to various hydrophilic antifolates.Semantic proximity Read ↗

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Escape from hsa-miR-519c enables drug-resistant cells to maintain high expression of ABCG2Semantic proximity Read ↗

A phenotype conferring selective resistance to lipophilic antifolates in Chinese hamster ovary cells.Semantic proximity Read ↗

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