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Article

Computational model for the IGF-II/IGF2r complex that is predictive of mutational and surface plasmon resonance data.

Proteins - 15 Aug 2006

Roche Philippe, Brown James, Denley Adam, Forbes Briony E, Wallace John C, Jones E Yvonne, Esnouf Robert M

Abstract excerpt

Insulin-like growth factors (IGFs) are key regulators of cell proliferation, differentiation, and transformation, and are thus pivotal in cancer, especially breast, prostate, and colon neoplasm. Their potent mitogenic and anti-apoptotic actions depend primarily on their availability to bind to the signaling IGF cell surface receptors. One mechanism by which IGF-II availability is thought to be modulated is by...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16741994
DOI: 10.1002/prot.21035

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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