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Article

A common nonsense mutation in EphB2 is associated with prostate cancer risk in African American men with a positive family history.

Journal of medical genetics - 1 Jun 2006

Kittles R A, Baffoe-Bonnie A B, Moses T Y, Robbins C M, Ahaghotu C, Huusko P, Pettaway C, Vijayakumar S, Bennett J, Hoke G, Mason T, Weinrich S, Trent J M, Collins F S, Mousses S, Bailey-Wilson J, Furbert-Harris P, Dunston G, Powell I J, Carpten J D

Abstract excerpt

BACKGROUND: The EphB2 gene was recently implicated as a prostate cancer (PC) tumour suppressor gene, with somatic inactivating mutations occurring in approximately 10% of sporadic tumours. We evaluated the contribution of EphB2 to inherited PC susceptibility in African Americans (AA) by screening the gene for germline polymorphisms. METHODS: Direct sequencing of the coding region of EphB2 was performed on 72...

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Identifiers

PMID: 16155194
DOI: 10.1136/jmg.2005.035790
PMCID: PMC2564535

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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