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Article

The DNA-binding Domain of Human Papillomavirus Type 18 E1

1 Jan 2004

Abstract excerpt

High risk types of human papillomavirus, such as type 18 (HPV-18), cause cervical carcinoma, one of the most frequent causes of cancer death in women worldwide. DNA replication is one of the central processes in viral maintenance, and the machinery involved is an excellent target for the design of antiviral therapy. The papillomaviral DNA replication initiation protein E1 has origin recognition and ATP-dependent...

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PMID: 14593106
DOI: 10.1074/jbc.m311681200

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