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Article

Mechanistic analysis of local ori melting and helicase assembly by the papillomavirus E1 protein.

Molecular cell - 2 Sept 2011

Schuck Stephen, Stenlund Arne

Abstract excerpt

Preparation of DNA templates for replication requires opening of the duplex to expose single-stranded (ss) DNA. The locally melted DNA is required for replicative DNA helicases to initiate unwinding. How local melting is generated in eukaryotic replicons is unknown, but initiator proteins from a handful of eukaryotic viruses can perform this function. Here we dissect the local melting process carried out by the...

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Identifiers

PMID: 21884978
DOI: 10.1016/j.molcel.2011.06.026
PMCID: PMC3209524

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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