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Eph Receptors and Ephrins: Therapeutic Opportunities

8 Oct 2014

Abstract excerpt

The erythropoietin-producing hepatocellular carcinoma (Eph) receptor tyrosine kinase family plays important roles in developmental processes, adult tissue homeostasis, and various diseases. Interaction with Eph receptor-interacting protein (ephrin) ligands on the surface of neighboring cells triggers Eph receptor kinase-dependent signaling. The ephrins can also transmit signals, leading to bidirectional cell...

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PMID: 25292427
DOI: 10.1146/annurev-pharmtox-011112-140226

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