A role for the scaffolding adapter GAB2 in breast cancer.

doi:10.1038/nm1341

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Article

A role for the scaffolding adapter GAB2 in breast cancer.

Nature medicine - 1 Jan 2006

Bentires-Alj Mohamed, Gil Susana G, Chan Richard, Wang Zhigang C, Wang Yongping, Imanaka Naoko, Harris Lyndsay N, Richardson Andrea, Neel Benjamin G, Gu Haihua

Abstract excerpt

The scaffolding adapter GAB2 maps to a region (11q13-14) commonly amplified in human breast cancer, and is overexpressed in breast cancer cell lines and primary tumors, but its functional role in mammary carcinogenesis has remained unexplored. We found that overexpression of GAB2 (Grb2-associated binding protein 2) increases proliferation of MCF10A mammary cells in three-dimensional culture. Coexpression of GAB2...

Topics

Adaptor Proteins, Signal Transducing
Animals
Breast Neoplasms
Cell Culture Techniques
Cell Line
Cell Line, Tumor
Chromosome Mapping
Crosses, Genetic
Extracellular Signal-Regulated MAP Kinases
Female

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Gene Expression Regulation, Neoplastic

Humans

Immunohistochemistry

In Situ Hybridization, Fluorescence

Intracellular Signaling Peptides and Proteins

Ki-67 Antigen

Male

Mammary Neoplasms, Animal

Source

Open in PubMed

Identifiers

PMID: 16369543
DOI: 10.1038/nm1341

Genes

GAB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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