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Article

A role for the scaffolding adapter GAB2 in breast cancer.

Nature medicine - 1 Jan 2006

Bentires-Alj Mohamed, Gil Susana G, Chan Richard, Wang Zhigang C, Wang Yongping, Imanaka Naoko, Harris Lyndsay N, Richardson Andrea, Neel Benjamin G, Gu Haihua

Abstract excerpt

The scaffolding adapter GAB2 maps to a region (11q13-14) commonly amplified in human breast cancer, and is overexpressed in breast cancer cell lines and primary tumors, but its functional role in mammary carcinogenesis has remained unexplored. We found that overexpression of GAB2 (Grb2-associated binding protein 2) increases proliferation of MCF10A mammary cells in three-dimensional culture. Coexpression of GAB2...

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Source

Identifiers

PMID: 16369543
DOI: 10.1038/nm1341

Genes

GAB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

A role for the scaffolding adapter GAB2 in breast cancer.PMID 16369543Read ↗

Increased proliferation and altered growth factor dependence of human mammary epithelial cells overexpressing the Gab2 docking protein.Semantic proximity Read ↗

For a systematic comprehension of GAB2: an analysis based on pan-cancerSemantic proximity Read ↗

The GAB2 signaling scaffold promotes anchorage independence and drives a transcriptional response associated with metastatic progression of breast cancerSemantic proximity Read ↗

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Gab2 regulates cytoskeletal organization and migration of mammary epithelial cells by modulating RhoA activation.Semantic proximity Read ↗

Gab1 is required for EGF receptor signaling and the transformation by activated ErbB2.Semantic proximity Read ↗

Grb2 and Shc adapter proteins play distinct roles in Neu (ErbB-2)-induced mammary tumorigenesis: implications for human breast cancer.Semantic proximity Read ↗

GRB2 is a BECN1 interacting protein that regulates autophagySemantic proximity Read ↗

Grb2 overexpression in nuclei and cytoplasm of human breast cells: a histochemical and biochemical study of normal and neoplastic mammary tissue specimensSemantic proximity Read ↗

Gab2-mediated signaling promotes melanoma metastasis.Semantic proximity Read ↗

Phosphotyrosines 627 and 659 of Gab1 constitute a bisphosphoryl tyrosine-based activation motif (BTAM) conferring binding and activation of SHP2.Semantic proximity Read ↗

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