Article
Cadherin conformations associated with dimerization and adhesion.
The Journal of biological chemistry - 27 Apr 2007
Tsuiji Hitomi, Xu Liang, Schwartz Kathleen, Gumbiner Barry M
Abstract excerpt
To investigate conformations of C-cadherin associated with functional activity and physiological regulation, we generated monoclonal antibodies (mAbs) that bind differentially to monomeric or dimeric forms. These mAbs recognize conformational epitopes at multiple sites along the C-cadherin ectodomain aside from the well known Trp-2-mediated dimer interface in the N-terminal EC1 domain. Group 1 mAbs, which bind...
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