Article
Cyclin D1 harboring the T286I mutation promotes oncogenic activation in endometrial cancer.
Oncology reports - 1 Aug 2013
Ikeda Yuji, Oda Katsutoshi, Hiraike-Wada Osamu, Koso Takahiro, Miyasaka Aki, Kashiyama Tomoko, Tanikawa Michihiro, Sone Kenbun, Nagasaka Kazunori, Maeda Daichi, Kawana Kei, Nakagawa Shunsuke, Fukayama Masashi, Tetsu Osamu, Fujii Tomoyuki, Yano Tetsu, Kozuma Shiro
Abstract excerpt
Cyclin D1 is an important regulator of cell cycle progression. Phosphorylation of cyclin D1 at Thr286 by GSK3β triggers its nuclear export and cytoplasmic proteolysis via the 26S proteasome. Cyclin D1 overexpression is a common event in various types of human cancers; however, reports of mutations are extremely rare. We analyzed mutations of the cyclin D1 gene, CCND1, in 88 endometrial cancer tissue specimens and...
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