Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The role of reactive oxygen species and subsequent DNA-damage response in the emergence of resistance towards resveratrol in colon cancer models

20 Nov 2014

Abstract excerpt

In spite of the novel strategies to treat colon cancer, mortality rates associated with this disease remain consistently high. Tumour recurrence has been linked to the induction of resistance towards chemotherapy that involves cellular events that enable cancer cells to escape cell death. Treatment of colon cancer mainly implicates direct or indirect DNA-damaging agents and increased repair or tolerances towards...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to PARP inhibition in cancer therapy
Share to Sirtuins and Resveratrol in Medicine
Share to Tea Polyphenols and Effects

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 25412311
DOI: 10.1038/cddis.2014.486

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The role of reactive oxygen species and subsequent DNA-damage response in the emergence of resistance towards resveratrol in colon cancer modelsPMID 25412311Read ↗

Emerging actionable targets to treat therapy-resistant colorectal cancersSemantic proximity Read ↗

Resveratrol induces colon tumor cell apoptosis independently of p53 and precede by epithelial differentiation, mitochondrial proliferation and membrane potential collapseSemantic proximity Read ↗

Inhibition of Cancer Development by Natural Plant Polyphenols: Molecular MechanismsSemantic proximity Read ↗

Reactive oxygen species and colorectal cancer.Semantic proximity Read ↗

Senolytic Flavonoids Enhance Type-I and Type-II Cell Death in Human Radioresistant Colon Cancer Cells through AMPK/MAPK PathwaySemantic proximity Read ↗

CHK1 inhibitor sensitizes resistant colorectal cancer stem cells to nortopsentinSemantic proximity Read ↗

Reactive Oxygen Species as Mediators of Disease Progression and Therapeutic Response in Colorectal CancerSemantic proximity Read ↗

Recent Updates on Mechanisms of Resistance to 5-Fluorouracil and Reversal Strategies in Colon Cancer TreatmentSemantic proximity Read ↗

Acquisition of anticancer drug resistance is partially associated with cancer stemness in human colon cancer cells.Semantic proximity Read ↗

Chemosensitivity of human colon cancer cells is influenced by a p53-dependent enhancement of ceramide synthase 5 and induction of autophagySemantic proximity Read ↗

Natural polyphenols facilitate elimination of HT-29 colorectal cancer xenografts by chemoradiotherapy: a Bcl-2- and superoxide dismutase 2-dependent mechanismSemantic proximity Read ↗

DNA repair capacity and response to treatment of colon cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.